Autopoietic Influence Hierarchies in Pancreatic β Cells

Dean Korošak, Marko Jusup, Boris Podobnik, Andraž Stožer, Jurij Dolenšek, Petter Holme, and Marjan Slak Rupnik
Phys. Rev. Lett. 127, 168101 – Published 11 October 2021
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Abstract

β cells are biologically essential for humans and other vertebrates. Because their functionality arises from cell-cell interactions, they are also a model system for collective organization among cells. There are currently two contradictory pictures of this organization: the hub-cell idea pointing at leaders who coordinate the others, and the electrophysiological theory describing all cells as equal. We use new data and computational modeling to reconcile these pictures. We find via a network representation of interacting β cells that leaders emerge naturally (confirming the hub-cell idea), yet all cells can take the hub role following a perturbation (in line with electrophysiology).

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  • Received 7 January 2021
  • Accepted 9 September 2021

DOI:https://doi.org/10.1103/PhysRevLett.127.168101

© 2021 American Physical Society

Physics Subject Headings (PhySH)

Statistical Physics & ThermodynamicsInterdisciplinary PhysicsNetworksPhysics of Living Systems

Authors & Affiliations

Dean Korošak1,2, Marko Jusup3, Boris Podobnik4,5,6,7,8, Andraž Stožer1, Jurij Dolenšek1,9, Petter Holme3,*, and Marjan Slak Rupnik1,10,11,†

  • 1Institute of Physiology, Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia
  • 2Faculty of Civil Engineering, Transportation Engineering and Architecture, University of Maribor, 2000 Maribor, Slovenia
  • 3Tokyo Tech World Research Hub Initiative (WRHI), Institute of Innovative Research, Tokyo Institute of Technology, Tokyo 152-8552, Japan
  • 4Faculty of Civil Engineering, University of Rijeka, 51000 Rijeka, Croatia
  • 5Center for Polymer Studies, Boston University, Boston, Massachusetts 02215, USA
  • 6Zagreb School of Economics and Management, 10000 Zagreb, Croatia
  • 7Luxembourg School of Business, 2453 Luxembourg, Luxembourg
  • 8Faculty of Information Studies in Novo mesto, 8000 Novo Mesto, Slovenia
  • 9Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia
  • 10Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria
  • 11Alma Mater Europaea—European Center Maribor, 2000 Maribor, Slovenia

  • *Corresponding author. holme@cns.pi.titech.ac.jp
  • Corresponding author. marjan.slakrupnik@meduniwien.ac.at

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Issue

Vol. 127, Iss. 16 — 15 October 2021

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