• Open Access

Nonequilibrium polarity-induced chemotaxis: Emergent Galilean symmetry and exact scaling exponents

Saeed Mahdisoltani, Riccardo Ben Alì Zinati, Charlie Duclut, Andrea Gambassi, and Ramin Golestanian
Phys. Rev. Research 3, 013100 – Published 29 January 2021

Abstract

A generically observed mechanism that drives the self-organization of living systems is interaction via chemical signals among the individual elements—which may represent cells, bacteria, or even enzymes. Here we propose an unconventional mechanism for such interactions, in the context of chemotaxis, which originates from the polarity of the particles and which generalizes the well-known Keller-Segel interaction term. We study the resulting large-scale dynamical properties of a system of such chemotactic particles using the exact stochastic formulation of Dean and Kawasaki along with dynamical renormalization group analysis of the critical state of the system. At this critical point, an emergent “Galilean” symmetry is identified, which allows us to obtain the dynamical scaling exponents exactly. These exponents reveal superdiffusive density fluctuations and non-Poissonian number fluctuations. We expect our results to shed light on how molecular regulation of chemotactic circuits can determine large-scale behavior of cell colonies and tissues.

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  • Received 18 November 2019
  • Revised 21 October 2020
  • Accepted 23 December 2020

DOI:https://doi.org/10.1103/PhysRevResearch.3.013100

Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Open access publication funded by the Max Planck Society.

Published by the American Physical Society

Physics Subject Headings (PhySH)

Physics of Living Systems

Authors & Affiliations

Saeed Mahdisoltani1,2,*, Riccardo Ben Alì Zinati3,*, Charlie Duclut4,*, Andrea Gambassi3, and Ramin Golestanian1,2,†

  • 1Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford OX1 3PU, United Kingdom
  • 2Max Planck Institute for Dynamics and Self-Organization (MPIDS), D-37077 Göttingen, Germany
  • 3SISSA—International School for Advanced Studies & INFN, I-34136 Trieste, Italy
  • 4Max-Planck-Institut für Physik komplexer Systeme, D-01187 Dresden, Germany

  • *These authors contributed equally to this work.
  • ramin.golestanian@ds.mpg.de

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Vol. 3, Iss. 1 — January - March 2021

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