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Tip-Enhanced Coherent Anti-Stokes Raman Scattering for Vibrational Nanoimaging

Taro Ichimura, Norihiko Hayazawa, Mamoru Hashimoto, Yasushi Inouye, and Satoshi Kawata
Phys. Rev. Lett. 92, 220801 – Published 2 June 2004
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Abstract

An electric field enhanced by a metallic nanoprobe has locally induced coherent anti-Stokes Raman scattering (CARS) of adenine molecules in a nanometric DNA network structure. Owing to the third-order nonlinearity, the excitation of the CARS polarization is extremely confined to the end of the tip apex, resulting in a spatial resolution far beyond the diffraction limit of light. Our tip-enhanced CARS microscope visualized the DNA network structure at a specific vibrational frequency (1337cm1) corresponding to the ring-breathing mode of diazole of adenine molecules.

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  • Received 17 October 2003

DOI:https://doi.org/10.1103/PhysRevLett.92.220801

©2004 American Physical Society

Authors & Affiliations

Taro Ichimura1, Norihiko Hayazawa1,4, Mamoru Hashimoto2,4, Yasushi Inouye3,4,5,*, and Satoshi Kawata1,4,5

  • 1Department of Applied Physics, Osaka University, Suita, Osaka 565-0871, Japan
  • 2Department of Mechanical Engineering and Bioengineering, Osaka University, Toyonaka, Osaka 560-8531, Japan
  • 3Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan
  • 4CREST, Japan Corporation of Science and Technology, Japan
  • 5RIKEN, Wako, Saitama, 351-0198, Japan

  • *Corresponding author. Email address: ya-inoue@ap.eng.osaka-u.ac.jp

See Also

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Adrian Cho
Phys. Rev. Focus 13, 24 (2004)

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Issue

Vol. 92, Iss. 22 — 4 June 2004

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