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Statistical Breakage of Single Protein A-IgG Bonds Reveals Crossover from Spontaneous to Force-Induced Bond Dissociation

D. A. Simson, M. Strigl, M. Hohenadl, and R. Merkel
Phys. Rev. Lett. 83, 652 – Published 19 July 1999
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Abstract

Dynamic force spectroscopy was applied to single specific bonds between immunoglobulins of type G and protein A, a staphylococcal receptor for IgG. The resulting spectra of yield forces indicated the crossover from force induced to spontaneous bond dissociation. Moreover, failure of unloaded bonds was observed directly. Extrapolation to vanishing loading rate and direct observation yielded coinciding results.

  • Received 7 December 1998

DOI:https://doi.org/10.1103/PhysRevLett.83.652

©1999 American Physical Society

Authors & Affiliations

D. A. Simson, M. Strigl, M. Hohenadl, and R. Merkel

  • Lehrstuhl für Biophysik E22, Technische Universität München, James-Franck-Strasse 1, D-85748 Garching, Germany

See Also

Breaking Single Protein Bonds

Phys. Rev. Focus 4, 4 (1999)

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Issue

Vol. 83, Iss. 3 — 19 July 1999

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