Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering

Andreas Zumbusch; Gary R. Holtom; X. Sunney Xie

doi:10.1103/PhysRevLett.82.4142

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Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering

Andreas Zumbusch, Gary R. Holtom, and X. Sunney Xie

Phys. Rev. Lett. 82, 4142 – Published 17 May 1999

Abstract

A multiphoton microscopy based on coherent anti-Stokes Raman scattering is accomplished with near-infrared ultrashort laser pulses. We demonstrate vibrational imaging of chemical and biological samples with high sensitivity, high spatial resolution, noninvasiveness, and three-dimensional sectioning capability.

Received 9 December 1998

DOI:https://doi.org/10.1103/PhysRevLett.82.4142

Authors & Affiliations

Andreas Zumbusch^*, Gary R. Holtom, and X. Sunney Xie^†

Pacific Northwest National Laboratory, William R. Wiley Environmental Molecular Sciences Laboratory, P.O. Box 999, K8-88, Richland, Washington 99352

^*Present address: Institute für Physikalische Chemie, Universität München, Butenandtstr. 5-13 Haus E, D-81377 München, Germany.
^†Present address: Harvard University, Department of Chemistry and Chemical Biology, 12 Oxford Street, Cambridge, MA 01238.

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Vol. 82, Iss. 20 — 17 May 1999

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