Abstract
We explore the rate-dependent dynamic response of periodically paced bullfrog (Rana catesbeiana) cardiac muscle. Alternans (2:2 behavior) occur in of animals and bistability in of animals. In addition, we observe bistablility. We discuss the implications of these results for two map-based models of cardiac dynamics. The high prevalence of bistability suggests that this dynamical behavior must be accounted for in the design of closed-loop feedback protocols to stabilize cardiac dynamics.
- Received 13 July 1998
DOI:https://doi.org/10.1103/PhysRevLett.82.2995
©1999 American Physical Society