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High-Frequency Mechanical Properties of Tumors Measured by Brillouin Light Scattering

Jérémie Margueritat, Angélique Virgone-Carlotta, Sylvain Monnier, Hélène Delanoë-Ayari, Hichem C. Mertani, Alice Berthelot, Quentin Martinet, Xavier Dagany, Charlotte Rivière, Jean-Paul Rieu, and Thomas Dehoux
Phys. Rev. Lett. 122, 018101 – Published 8 January 2019
Physics logo See Synopsis: Mapping a Tumor’s Mechanical Properties with Light
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Abstract

The structure of tumors can be recapitulated as an elastic frame formed by the connected cytoskeletons of the cells invaded by interstitial and intracellular fluids. The low-frequency mechanics of this poroelastic system, dictated by the elastic skeleton only, control tumor growth, penetration of therapeutic agents, and invasiveness. The high-frequency mechanical properties containing the additional contribution of the internal fluids have also been posited to participate in tumor progression and drug resistance, but they remain largely unexplored. Here we use Brillouin light scattering to produce label-free images of tumor microtissues based on the high-frequency viscoelastic modulus as a contrast mechanism. In this regime, we demonstrate that the modulus discriminates between tissues with altered tumorigenic properties. Our micrometric maps also reveal that the modulus is heterogeneously altered across the tissue by drug therapy, revealing a lag of efficacy in the core of the tumor. Exploiting high-frequency poromechanics should advance present theories based on viscoelasticity and lead to integrated descriptions of tumor response to drugs.

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  • Received 7 June 2018

DOI:https://doi.org/10.1103/PhysRevLett.122.018101

© 2019 American Physical Society

Physics Subject Headings (PhySH)

  1. Physical Systems
Polymers & Soft MatterPhysics of Living Systems

Synopsis

Key Image

Mapping a Tumor’s Mechanical Properties with Light

Published 8 January 2019

A new experiment uses a light probe to measure the mechanical response of a tumor, which provides information about its anatomy and the efficacy of therapeutic agents.

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Authors & Affiliations

Jérémie Margueritat1, Angélique Virgone-Carlotta1, Sylvain Monnier1, Hélène Delanoë-Ayari1, Hichem C. Mertani2, Alice Berthelot1, Quentin Martinet1, Xavier Dagany1, Charlotte Rivière1, Jean-Paul Rieu1, and Thomas Dehoux1,*

  • 1Institut Lumière Matière, UMR5306, Université Lyon 1-CNRS, Université de Lyon, 69622 Villeurbanne, France
  • 2Université de Lyon, Université Lyon 1, INSERM U1052, CNRS UMR 5286, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France

  • *thomas.dehoux@univ-lyon1.fr

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Issue

Vol. 122, Iss. 1 — 11 January 2019

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