General Theory of Genotype to Phenotype Mapping: Derivation of Epigenetic Landscapes from N-Node Complex Gene Regulatory Networks

Carlos Villarreal, Pablo Padilla-Longoria, and Elena R. Alvarez-Buylla
Phys. Rev. Lett. 109, 118102 – Published 12 September 2012
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Abstract

We propose a systematic methodology to construct a probabilistic epigenetic landscape of cell-fate attainment associated with N-node Boolean genetic regulatory networks. The general derivation proposed here is exemplified with an Arabidopsis thaliana network underlying floral organ determination grounded on qualitative experimental data.

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  • Received 29 November 2011

DOI:https://doi.org/10.1103/PhysRevLett.109.118102

© 2012 American Physical Society

Authors & Affiliations

Carlos Villarreal1,4, Pablo Padilla-Longoria2,4, and Elena R. Alvarez-Buylla3,4,*

  • 1Instituto de Física, Universidad Nacional Autónoma de México, D.F. México, Mexico
  • 2Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas, Universidad Nacional Autónoma de México, D.F. México, Mexico
  • 3Instituto de Ecología, Universidad Nacional Autónoma de México, D.F. México, Mexico
  • 4Centro de Ciencias de la Complejidad, C3, Universidad Nacional Autónoma de México, D.F. México, Mexico

  • *Corresponding author. eabuylla@gmail.com

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Issue

Vol. 109, Iss. 11 — 14 September 2012

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