Inferring Where and When Replication Initiates from Genome-Wide Replication Timing Data

A. Baker, B. Audit, S. C.-H. Yang (楊正炘), J. Bechhoefer, and A. Arneodo
Phys. Rev. Lett. 108, 268101 – Published 29 June 2012; Erratum Phys. Rev. Lett. 109, 039901 (2012)

Abstract

Based on an analogy between DNA replication and one dimensional nucleation-and-growth processes, various attempts to infer the local initiation rate I(x,t) of DNA replication origins from replication timing data have been developed in the framework of phase transition kinetics theories. These works have all used curve-fit strategies to estimate I(x,t) from genome-wide replication timing data. Here, we show how to invert analytically the Kolmogorov-Johnson-Mehl-Avrami model and extract I(x,t) directly. Tests on both simulated and experimental budding-yeast data confirm the location and firing-time distribution of replication origins.

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  • Received 11 April 2012
  • Publisher error corrected 3 July 2012

DOI:https://doi.org/10.1103/PhysRevLett.108.268101

© 2012 American Physical Society

Corrections

3 July 2012

Erratum

Publisher’s Note: Inferring Where and When Replication Initiates from Genome-Wide Replication Timing Data [Phys. Rev. Lett. 108, 268101 (2012)]

A. Baker, B. Audit, S. C.-H. Yang (楊正炘), J. Bechhoefer, and A. Arneodo
Phys. Rev. Lett. 109, 039901 (2012)

Authors & Affiliations

A. Baker1, B. Audit1, S. C.-H. Yang (楊正炘)2, J. Bechhoefer2, and A. Arneodo1

  • 1Université de Lyon, F-69000 Lyon, France, and Laboratoire de Physique, ENS de Lyon, CNRS, F-69007 Lyon, France
  • 2Department of Physics, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada

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Issue

Vol. 108, Iss. 26 — 29 June 2012

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