Abstract
Based on an analogy between DNA replication and one dimensional nucleation-and-growth processes, various attempts to infer the local initiation rate of DNA replication origins from replication timing data have been developed in the framework of phase transition kinetics theories. These works have all used curve-fit strategies to estimate from genome-wide replication timing data. Here, we show how to invert analytically the Kolmogorov-Johnson-Mehl-Avrami model and extract directly. Tests on both simulated and experimental budding-yeast data confirm the location and firing-time distribution of replication origins.
- Received 11 April 2012
- Publisher error corrected 3 July 2012
DOI:https://doi.org/10.1103/PhysRevLett.108.268101
© 2012 American Physical Society
Corrections
3 July 2012