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New Light on Disordered Ensembles: Ab Initio Structure Determination of One Particle from Scattering Fluctuations of Many Copies

D. K. Saldin, H. C. Poon, M. J. Bogan, S. Marchesini, D. A. Shapiro, R. A. Kirian, U. Weierstall, and J. C. H. Spence
Phys. Rev. Lett. 106, 115501 – Published 14 March 2011
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Abstract

We report on the first experimental ab initio reconstruction of an image of a single particle from fluctuations in the scattering from an ensemble of copies, randomly oriented about an axis. The method is applicable to identical particles frozen in space or time (as by snapshot diffraction from an x-ray free electron laser). These fluctuations enhance information obtainable from an experiment such as conventional small angle x-ray scattering.

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  • Received 29 September 2010

DOI:https://doi.org/10.1103/PhysRevLett.106.115501

© 2011 American Physical Society

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Imaging matter in different spaces

Published 14 March 2011

An x-ray free electron laser setup converts the diffraction pattern of randomly positioned and oriented particles into an image of a single particle.

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Authors & Affiliations

D. K. Saldin1,2, H. C. Poon1, M. J. Bogan3, S. Marchesini4, D. A. Shapiro5, R. A. Kirian6, U. Weierstall6, and J. C. H. Spence6

  • 1Department of Physics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA
  • 2Kavli Institute for Theoretical Physics, University of California, Santa Barbara, California 93106, USA
  • 3Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, California 94025, USA
  • 4Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
  • 5Brookhaven National Laboratory, Upton, New York 11973, USA
  • 6Department of Physics, Arizona State University, Tempe, Arizona 85287, USA

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Issue

Vol. 106, Iss. 11 — 18 March 2011

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