Extreme value analysis of gut microbial alterations in colorectal cancer

S. D. Song, P. Jeraldo, J. Chen, and N. Chia
Phys. Rev. E 99, 032413 – Published 13 March 2019

Abstract

Gut microbes play a key role in colorectal carcinogenesis, yet reaching a consensus on microbial signatures remains a challenge. This is in part due to a reliance on mean value estimates. We present an extreme value analysis for overcoming these limitations. By characterizing a power-law fit to the relative abundances of microbes, we capture the same microbial signatures as more complex meta-analyses. Importantly, we show that our method is robust to the variations inherent in microbial community profiling and point to future directions for developing sensitive, reliable analytical methods.

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  • Received 25 July 2018

DOI:https://doi.org/10.1103/PhysRevE.99.032413

©2019 American Physical Society

Physics Subject Headings (PhySH)

Statistical Physics & ThermodynamicsPhysics of Living Systems

Authors & Affiliations

S. D. Song1, P. Jeraldo2,3, J. Chen4, and N. Chia2,3,*

  • 1Neuroscience Program, Wellesley College, 106 Central Street, Wellesley, Massachusetts 02481, USA
  • 2Microbiome Program, Center for Individualized Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
  • 3Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
  • 4Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA

  • *Chia.Nicholas@mayo.edu

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Vol. 99, Iss. 3 — March 2019

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