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Microstructured glass chip for ion-channel electrophysiology

N. Fertig, Ch. Meyer, R. H. Blick, Ch. Trautmann, and J. C. Behrends
Phys. Rev. E 64, 040901(R) – Published 21 September 2001
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Abstract

We present a technique by which it is possible to produce a planar sensor for ion channel electrophysiology from glass substrates. Apertures with diameters in the low micrometer to submicrometer range are achieved by irradiation of a glass chip with a single heavy ion and subsequent wet track etching. The function of the device is demonstrated by recordings of single channel currents mediated by the model ion channel gramicidin A in lipid bilayers spanning the micromachined aperture.

  • Received 18 May 2001

DOI:https://doi.org/10.1103/PhysRevE.64.040901

©2001 American Physical Society

Authors & Affiliations

N. Fertig1,2, Ch. Meyer1,2, R. H. Blick1, Ch. Trautmann3, and J. C. Behrends1,2

  • 1Center for NanoScience and Sektion Physik, Ludwig-Maximilians-Universität, Geschwister-Scholl-Platz 1, 80539 München, Germany
  • 2Physiologisches Institut, Ludwig-Maximilians-Universität, Pettenkoferstraße 12, 80336 Munich, Germany
  • 3Gesellschaft für Schwerionenforschung, Planckstraße 1, 64291 Darmstadt, Germany

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Vol. 64, Iss. 4 — October 2001

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