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Avalanche of bifurcations and hysteresis in a model of cellular differentiation

Gábor Fáth and Zbigniew Domański
Phys. Rev. E 60, 4604 – Published 1 October 1999
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Abstract

Cellular differentiation in a developing organism is studied via a discrete bistable reaction-diffusion model. A system of undifferentiated cells is allowed to receive an inductive signal emanating from its environment. Depending on the form of the nonlinear reaction kinetics, this signal can trigger a series of bifurcations in the system. Differentiation starts at the surface where the signal is received and either cells change type up to a given distance or, under other conditions, the differentiation process propagates throughout the whole domain. When the signal diminishes, hysteresis is observed.

  • Received 6 May 1999

DOI:https://doi.org/10.1103/PhysRevE.60.4604

©1999 American Physical Society

Authors & Affiliations

Gábor Fáth*

  • Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge CB3 0HE, England

Zbigniew Domański

  • Institute of Theoretical Physics, University of Lausanne, CH-1015 Lausanne, Switzerland
  • Institute of Mathematics and Computer Sciences, Technical University of Czȩstochowa, Da̧browskiego 69, PL-42200 Czȩstochowa, Poland

  • *Permanent address: Research Institute for Solid State Physics, P.O. Box 49, H-1525 Budapest, Hungary.

See Also

Equations for an Embryo

Phys. Rev. Focus 4, 20 (1999)

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Vol. 60, Iss. 4 — October 1999

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