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Design of conditions for self-replication

Sumantra Sarkar and Jeremy L. England
Phys. Rev. E 100, 022414 – Published 26 August 2019
An article within the collection: Irwin Oppenheim Award

Abstract

A “self-replicator” is usually understood to be an object of definite form that promotes the conversion of materials in its environment into a nearly identical copy of itself. The challenge of engineering novel, micro- or nanoscale self-replicators has attracted keen interest in recent years, both because exponential amplification is an attractive method for generating high yields of specific products and, also, because self-reproducing entities have the potential to be optimized or adapted through rounds of iterative selection. Substantial steps forward have been achieved both in the engineering of particular self-replicating molecules and in the characterization of the physical basis for possible mechanisms of self-replication. At present, however, there is a need for a theoretical treatment of what physical conditions are most conducive to the emergence of novel self-replicating structures from a reservoir of building blocks on a desired time scale. Here we report progress in addressing this need. By analyzing the kinetics of a toy chemical model, we demonstrate that the emergence of self-replication can be controlled by coarse, tunable features of the chemical system, such as the fraction of fast reactions and the width of the rate constant distribution. We also find that the typical mechanism is dominated by the cooperation of multiple interconnected reaction cycles as opposed to a single isolated cycle. The quantitative treatment presented here may prove useful for designing novel self-replicating chemical systems.

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  • Received 13 November 2018
  • Revised 23 June 2019

DOI:https://doi.org/10.1103/PhysRevE.100.022414

©2019 American Physical Society

Physics Subject Headings (PhySH)

  1. Research Areas
  1. Physical Systems
Physics of Living SystemsNetworks

Collections

This article appears in the following collection:

Irwin Oppenheim Award

Annual award recognizes outstanding contributions by early career scientists.

Authors & Affiliations

Sumantra Sarkar* and Jeremy L. England

  • Physics of Living Systems, Massachusetts Institute of Technology, 400 Technology Square, Cambridge, Massachusetts 02139, USA

  • *Present address: Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico 87544, USA; sumantra@lanl.gov
  • jengland@mit.edu

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Issue

Vol. 100, Iss. 2 — August 2019

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