Optical Funnel to Guide and Focus Virus Particles for X-Ray Diffractive Imaging

Salah Awel, Sebastian Lavin-Varela, Nils Roth, Daniel A. Horke, Andrei V. Rode, Richard A. Kirian, Jochen Küpper, and Henry N. Chapman
Phys. Rev. Applied 17, 044044 – Published 22 April 2022

Abstract

Photophoretic forces are induced when light causes a net momentum exchange between a particle and a surrounding gas. Such forces have been shown to be a robust means for trapping and guiding particles in air over long distances. Here, we apply the concept of an optical funnel for the delivery of bioparticles to the focus of an x-ray free-electron laser (XFEL) for femtosecond x-ray diffractive imaging. We provide the experimental demonstration of transversely compressing a high-speed beam of aerosolized viruses via photophoretic forces in a low-pressure gas environment. Relative temperature gradients induced on the viruses by the laser are estimated via particle-velocimetry measurements. The results demonstrate the potential for an optical funnel to improve particle-delivery efficiency in XFEL imaging and spectroscopy.

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  • Received 14 January 2022
  • Revised 17 March 2022
  • Accepted 22 March 2022

DOI:https://doi.org/10.1103/PhysRevApplied.17.044044

© 2022 American Physical Society

Physics Subject Headings (PhySH)

Atomic, Molecular & OpticalCondensed Matter, Materials & Applied PhysicsPhysics of Living Systems

Authors & Affiliations

Salah Awel1,2, Sebastian Lavin-Varela3, Nils Roth1,4, Daniel A. Horke1,5, Andrei V. Rode3,*, Richard A. Kirian6, Jochen Küpper1,2,4, and Henry N. Chapman1,2,4

  • 1Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron (DESY), Notkestrasse 85, Hamburg 22607, Germany
  • 2Center for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, Hamburg 22761, Germany
  • 3Laser Physics Centre, Research School of Physics, Australian National University, Canberra ACT 2601, Australia
  • 4Department of Physics, Universität Hamburg, Luruper Chaussee 149, Hamburg 22761, Germany
  • 5Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen 6525 AJ, Netherlands
  • 6Department of Physics, Arizona State University, Tempe, Arizona 85287, USA

  • *avr111@physics.anu.edu.au

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Vol. 17, Iss. 4 — April 2022

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