Translocation of DNA Molecules through Nanopores with Salt Gradients: The Role of Osmotic Flow

Marius M. Hatlo, Debabrata Panja, and René van Roij
Phys. Rev. Lett. 107, 068101 – Published 1 August 2011
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Abstract

Recent experiments of translocation of double-stranded DNA through nanopores [M. Wanunu et al., Nature Nanotech. 5, 160 (2009)] reveal that the DNA capture rate can be significantly influenced by a salt gradient across the pore. We show that osmotic flow combined with electrophoretic effects can quantitatively explain the experimental data on the salt-gradient dependence of the capture rate.

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  • Received 4 December 2010

DOI:https://doi.org/10.1103/PhysRevLett.107.068101

© 2011 American Physical Society

Authors & Affiliations

Marius M. Hatlo1,*, Debabrata Panja2, and René van Roij1

  • 1Institute for Theoretical Physics, Utrecht University, Leuvenlaan 4, 3584 CE Utrecht, The Netherlands
  • 2Institute for Theoretical Physics, Universiteit van Amsterdam, Science Park 904, Postbus 94485, 1090 GL Amsterdam, The Netherlands

  • *M.M.Hatlo@uu.nl

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Vol. 107, Iss. 6 — 5 August 2011

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