Signal Detection, Modularity, and the Correlation between Extrinsic and Intrinsic Noise in Biochemical Networks

Sorin Tănase-Nicola, Patrick B. Warren, and Pieter Rein ten Wolde
Phys. Rev. Lett. 97, 068102 – Published 8 August 2006

Abstract

We present an expression for the power spectrum of the output signal of a biochemical network, which reveals that the reactions that allow a network to detect biochemical signals, induce correlations between the extrinsic noise of the input signals and the intrinsic noise of the reactions that form the network. We show that anticorrelations between the extrinsic and intrinsic noise enhance the robustness of zero-order ultrasensitive networks to biochemical noise. We discuss the consequences for a modular description of noise transmission using the mitogen-activated protein kinase cascade.

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  • Received 23 March 2006

DOI:https://doi.org/10.1103/PhysRevLett.97.068102

©2006 American Physical Society

Authors & Affiliations

Sorin Tănase-Nicola1, Patrick B. Warren2, and Pieter Rein ten Wolde1

  • 1FOM Institute for Atomic and Molecular Physics, Kruislaan 407, 1098 SJ Amsterdam, The Netherlands
  • 2Unilever R&D Port Sunlight, Bebington, Wirral, CH63 3JW, United Kingdom

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Issue

Vol. 97, Iss. 6 — 11 August 2006

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