Pattern Formation within Escherichia coli: Diffusion, Membrane Attachment, and Self-Interaction of MinD Molecules

Rahul V. Kulkarni, Kerwyn Casey Huang, Morten Kloster, and Ned S. Wingreen
Phys. Rev. Lett. 93, 228103 – Published 23 November 2004

Abstract

In E. coli, accurate cell division depends upon the oscillation of Min proteins from pole to pole. We provide a model for the polar localization of MinD based only on diffusion, a delay for nucleotide exchange, and different rates of attachment to the bare membrane and the occupied membrane. We derive analytically the probability density, and correspondingly the length scale, for MinD attachment zones. Our simple analytical model illustrates the processes giving rise to the observed localization of cellular MinD zones.

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  • Received 6 January 2004

DOI:https://doi.org/10.1103/PhysRevLett.93.228103

©2004 American Physical Society

Authors & Affiliations

Rahul V. Kulkarni1,*, Kerwyn Casey Huang1,2,†, Morten Kloster1, and Ned S. Wingreen1,3

  • 1NEC Laboratories America, Inc., Princeton, New Jersey 08540, USA
  • 2Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
  • 3Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA

  • *Present address: Department of Physics, VirginiaTech, Blacksburg, VA 24061. Electronic address: kulkarni@vt.edu.
  • Present address: Department of Molecular Biology, Princeton University, Princeton, NJ 08540.

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Vol. 93, Iss. 22 — 26 November 2004

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