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Theory of Coherent and Incoherent Nuclear Spin Dephasing in the Heart

Wolfgang R. Bauer, Walter Nadler, Michael Bock, Lothar R. Schad, Christian Wacker, Andreas Hartlep, and Georg Ertl
Phys. Rev. Lett. 83, 4215 – Published 15 November 1999
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Abstract

We present an analytical theory of susceptibility induced nuclear spin dephasing in the capillary network of myocardium. Using a strong collision approach, equations are obtained for the relaxation rate of the free induction and the spin echo decay. Simulation and experimental data are well predicted by the theory. Since paramagnetic deoxyhemoglobin as the origin of nuclear spin dephasing has a higher tissue concentration in myocardium supplied by a stenotic, i.e., significantly narrowed, coronary artery, spin dephasing might serve as a diagnostic tool. Our approach can be modified for capillary networks in other tissues than myocardium and may be applied in material science.

  • Received 30 March 1999

DOI:https://doi.org/10.1103/PhysRevLett.83.4215

©1999 American Physical Society

Authors & Affiliations

Wolfgang R. Bauer1,*, Walter Nadler2, Michael Bock3, Lothar R. Schad3, Christian Wacker1, Andreas Hartlep2, and Georg Ertl1

  • 1II. Medizinische Klinik, Klinikum Mannheim/Universität Heidelberg, Theodor-Kutzer Ufer 1-3, D-68167 Mannheim, Germany
  • 2HLRZ/NIC c/o Forschungszentrum Jülich, D-52725 Jülich, Germany
  • 3Department of Biophysics, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany

  • *Corresponding author. Present address: Medizinische Universitäts Klinik, Josef Schneider Strasse 2, 97080 Würzburg, Germany.

See Also

Imaging the Heart’s Blood Supply

Phys. Rev. Focus 4, 25 (1999)

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Vol. 83, Iss. 20 — 15 November 1999

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