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Noise-Induced Acceleration of Single Molecule Kinesin-1

Takayuki Ariga, Keito Tateishi, Michio Tomishige, and Daisuke Mizuno
Phys. Rev. Lett. 127, 178101 – Published 22 October 2021
Physics logo See Focus story: Continuous Jostling Helps Protein Perform
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Abstract

The movement of single kinesin molecules was observed while applying noisy external forces that mimic intracellular active fluctuations. We found kinesin accelerates under noise, especially when a large hindering load is added. The behavior quantitatively conformed to a theoretical model that describes the kinesin movement with simple two-state reactions. The universality of the kinetic theory suggests that intracellular enzymes share a similar noise-induced acceleration mechanism, i.e., active fluctuations in cells are not just noise but are utilized to promote various physiological processes.

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  • Received 16 March 2021
  • Accepted 8 September 2021

DOI:https://doi.org/10.1103/PhysRevLett.127.178101

© 2021 American Physical Society

Physics Subject Headings (PhySH)

Physics of Living Systems

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Continuous Jostling Helps Protein Perform

Published 22 October 2021

Kinesin, which moves cargo around inside cells, moves faster with constant buffeting than without, suggesting that it’s optimized for the cellular environment.

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Authors & Affiliations

Takayuki Ariga1,*, Keito Tateishi1, Michio Tomishige2, and Daisuke Mizuno3

  • 1Graduate School of Medicine, Yamaguchi University, 755-8505 Yamaguchi, Japan
  • 2Department of Physical Sciences, Aoyama Gakuin University, 252-5258 Kanagawa, Japan
  • 3Department of Physics, Kyushu University, 819-0395 Fukuoka, Japan

  • *ariga@yamaguchi-u.ac.jp

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Issue

Vol. 127, Iss. 17 — 22 October 2021

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