Cell Cycle Heritability and Localization Phase Transition in Growing Populations

Takashi Nozoe and Edo Kussell
Phys. Rev. Lett. 125, 268103 – Published 29 December 2020
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Abstract

The cell cycle duration is a variable cellular phenotype that underlies long-term population growth and age structures. By analyzing the stationary solutions of a branching process with heritable cell division times, we demonstrate the existence of a phase transition, which can be continuous or first order, by which a nonzero fraction of the population becomes localized at a minimal division time. Just below the transition, we demonstrate the coexistence of localized and delocalized age-structure phases and the power law decay of correlation functions. Above it, we observe the self-synchronization of cell cycles, collective divisions, and the slow “aging” of population growth rates.

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  • Received 7 April 2020
  • Accepted 27 October 2020

DOI:https://doi.org/10.1103/PhysRevLett.125.268103

© 2020 American Physical Society

Physics Subject Headings (PhySH)

Statistical Physics & ThermodynamicsPhysics of Living Systems

Authors & Affiliations

Takashi Nozoe1 and Edo Kussell1,2

  • 1Department of Biology, New York University, 12 Waverly Place, New York, New York 10003, USA
  • 2Department of Physics, New York University, 726 Broadway, New York, New York 10003, USA

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Issue

Vol. 125, Iss. 26 — 31 December 2020

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