Abstract
We present a method to sample reactive pathways via biased molecular dynamics simulations in trajectory space. We show that the use of enhanced sampling techniques enables unconstrained exploration of multiple reaction routes. Time correlation functions are conveniently computed via reweighted averages along a single trajectory and kinetic rates are accessed at no additional cost. These abilities are illustrated analyzing a model potential and the umbrella inversion of in water. The algorithm allows a parallel implementation and promises to be a powerful tool for the study of rare events.
- Received 17 February 2020
- Revised 9 May 2020
- Accepted 12 June 2020
DOI:https://doi.org/10.1103/PhysRevLett.125.026001
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