Abstract
Nonequilibrium energetics of single molecule translational motor kinesin was investigated by measuring heat dissipation from the violation of the fluctuation-response relation of a probe attached to the motor using optical tweezers. The sum of the dissipation and work did not amount to the input free energy change, indicating large hidden dissipation exists. Possible sources of the hidden dissipation were explored by analyzing the Langevin dynamics of the probe, which incorporates the two-state Markov stepper as a kinesin model. We conclude that internal dissipation is dominant.
- Received 18 April 2017
- Revised 18 July 2018
DOI:https://doi.org/10.1103/PhysRevLett.121.218101
© 2018 American Physical Society
Physics Subject Headings (PhySH)
Viewpoint
Low Efficiency Spotted in a Molecular Motor
Published 21 November 2018
A detailed study of kinesin—a molecular motor responsible for transporting cellular cargo—shows that it loses 80% of input energy to heat.
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