Ionic Current Inversion in Pressure-Driven Polymer Translocation through Nanopores

Sahin Buyukdagli, Ralf Blossey, and T. Ala-Nissila
Phys. Rev. Lett. 114, 088303 – Published 26 February 2015

Abstract

We predict streaming current inversion with multivalent counterions in hydrodynamically driven polymer translocation events from a correlation-corrected charge transport theory including charge fluctuations around mean-field electrostatics. In the presence of multivalent counterions, electrostatic many-body effects result in the reversal of the DNA charge. The attraction of anions to the charge-inverted DNA molecule reverses the sign of the ionic current through the pore. Our theory allows for a comprehensive understanding of the complex features of the resulting streaming currents. The underlying mechanism is an efficient way to detect DNA charge reversal in pressure-driven translocation experiments with multivalent cations.

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  • Received 7 October 2014

DOI:https://doi.org/10.1103/PhysRevLett.114.088303

© 2015 American Physical Society

Authors & Affiliations

Sahin Buyukdagli1,2,*, Ralf Blossey2,†, and T. Ala-Nissila3,4,‡

  • 1Department of Physics, Bilkent University, Ankara 06800, Turkey
  • 2Institut de Recherche Interdisciplinaire USR3078 CNRS and Université Lille I, Parc de la Haute Borne, 52 Avenue de Halley, 59658 Villeneuve d’Ascq, France
  • 3Department of Applied Physics and COMP Center of Excellence, Aalto University School of Science, P.O. Box 11000, FI-00076 Aalto, Espoo, Finland
  • 4Department of Physics, Brown University, Providence, Box 1843, Rhode Island 02912-1843, USA

  • *Buyukdagli@fen.bilkent.edu.tr
  • Ralf.Blossey@iri.univ-lille1.fr
  • Tapio.Ala-Nissila@aalto.fi

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Vol. 114, Iss. 8 — 27 February 2015

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