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Elastic and Conformational Softness of a Globular Protein

Liang Hong, Dennis C. Glass, Jonathan D. Nickels, Stefania Perticaroli, Zheng Yi, Madhusudan Tyagi, Hugh O’Neill, Qiu Zhang, Alexei P. Sokolov, and Jeremy C. Smith
Phys. Rev. Lett. 110, 028104 – Published 10 January 2013; Erratum Phys. Rev. Lett. 110, 069901 (2013)
Physics logo See Synopsis: Classifying Protein Wiggles
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Abstract

Flexibility, or softness, is crucial for protein function and consists of a conformational component, involving jumps between potential wells, and an elastic component, involving fluctuations within the wells. Combining molecular dynamics simulation with incoherent neutron scattering and light scattering measurements on green fluorescent protein, we reveal a relationship between the intrawell fluctuations and elastic moduli of the protein. This finding leads to a simple means of experimentally separating the conformational from the elastic atomic displacements.

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  • Received 1 November 2012
  • Corrected 29 January 2013

DOI:https://doi.org/10.1103/PhysRevLett.110.028104

© 2013 American Physical Society

Corrections

29 January 2013

Erratum

Publisher’s Note: Elastic and Conformational Softness of a Globular Protein [Phys. Rev. Lett. 110, 028104 (2013)]

Liang Hong, Dennis C. Glass, Jonathan D. Nickels, Stefania Perticaroli, Zheng Yi, Madhusudan Tyagi, Hugh O’Neill, Qiu Zhang, Alexei P. Sokolov, and Jeremy C. Smith
Phys. Rev. Lett. 110, 069901 (2013)

Synopsis

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Classifying Protein Wiggles

Published 10 January 2013

Two different mechanisms give a protein its required flexibility.

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Authors & Affiliations

Liang Hong1, Dennis C. Glass1,2, Jonathan D. Nickels3, Stefania Perticaroli3, Zheng Yi1, Madhusudan Tyagi4, Hugh O’Neill5,6, Qiu Zhang5, Alexei P. Sokolov3, and Jeremy C. Smith1,6,*

  • 1UT/ORNL Center for Molecular Biophysics, Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, Tennessee 37831-6309, USA
  • 2Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, Tennessee 37996-0840, USA
  • 3Joint Institute for Neutron Sciences, Department of Chemistry, Oak Ridge National Laboratory, University of Tennessee, P.O. Box 2008, MS-6453. Building 8630, Suite B201. Oak Ridge, Tennessee 37831, USA
  • 4National Institute of Standards and Technology Center for Neutron Research, 100 Bureau Drive, Gaithersburg, Maryland 20899, USA and Department of Materials Science and Engineering, University of Maryland, College Park, Maryland 20742, USA
  • 5Biology and Soft Matter Division, Oak Ridge National Lab, Oak Ridge, Tennessee 37931, USA
  • 6Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, USA

  • *Corresponding author. smithjc@ornl.gov

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Vol. 110, Iss. 2 — 11 January 2013

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