Overcharging in Biological Systems: Reversal of Electrophoretic Mobility of Aqueous Polyaspartate by Multivalent Cations

Anna Kubíčková, Tomáš Křížek, Pavel Coufal, Mario Vazdar, Erik Wernersson, Jan Heyda, and Pavel Jungwirth
Phys. Rev. Lett. 108, 186101 – Published 3 May 2012

Abstract

Charge reversal as an extreme case of charge compensation is directly observed by capillary electrophoresis for a negatively charged peptide in aqueous solutions of trivalent cations. Atomistic and coarse-grained simulations provide molecular interpretation of this effect showing that it is largely of electrostatic origin with a minor contribution of chemical specificity of the salt ions.

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  • Received 18 January 2012

DOI:https://doi.org/10.1103/PhysRevLett.108.186101

© 2012 American Physical Society

Authors & Affiliations

Anna Kubíčková1, Tomáš Křížek1, Pavel Coufal1, Mario Vazdar2,3, Erik Wernersson2, Jan Heyda4, and Pavel Jungwirth2,*

  • 1Charles University in Prague, Faculty of Science, Department of Analytical Chemistry, Albertov 2030, 12840 Prague 2, Czech Republic
  • 2Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, CZ-16610 Prague 6, Czech Republic
  • 3Rudjer Bošković Institute, Division of Organic Chemistry and Biochemistry, P.O. Box 180, HR-10002 Zagreb, Croatia
  • 4Institute für Physik, Humboldt Universität zu Berlin, Newtonstr. 15, 12489 Berlin, Germany

  • *pavel.jungwirth@uochb.cas.cz

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Vol. 108, Iss. 18 — 4 May 2012

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