Abstract
The relationship of base pair openings to DNA flexibility is examined. Published experimental data on the temperature dependence of the persistence length by two different groups are well described in terms of an inhomogeneous Kratky-Porot model with soft and hard joints, corresponding to open and closed base pairs, and sequence-dependent statistical information about the state of each pair provided by a Peyrard-Bishop-Dauxois (PBD) model calculation with no freely adjustable parameters.
- Received 4 October 2011
DOI:https://doi.org/10.1103/PhysRevLett.108.078104
© 2012 American Physical Society
Synopsis
Double, Double…Bubble
Published 16 February 2012
DNA flexibility depends on how strands separate, which, in turn, depends on temperature.
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