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Blood Vessel Deformations on Microsecond Time Scales by Ultrasonic Cavitation

Hong Chen, Wayne Kreider, Andrew A. Brayman, Michael R. Bailey, and Thomas J. Matula
Phys. Rev. Lett. 106, 034301 – Published 18 January 2011
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Abstract

Transient interactions among ultrasound, microbubbles, and microvessels were studied using high-speed photomicrography. We observed liquid jets, vessel distention (motion outward against the surrounding tissue), and vessel invagination (motion inward toward the lumen). Contrary to current paradigms, liquid jets were directed away from the nearest vessel wall and invagination exceeded distention. These observations provide insight into the mechanics of bubble-vessel interactions, which appear to depend qualitatively upon the mechanical properties of biological tissues.

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  • Received 14 May 2010

DOI:https://doi.org/10.1103/PhysRevLett.106.034301

© 2011 American Physical Society

Synopsis

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Bubble trouble

Published 31 January 2011

Measurements of microbubbles in blood vessels under ultrasonic exposure show complex behavior that might relate to potential tissue damage.

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Authors & Affiliations

Hong Chen, Wayne Kreider, Andrew A. Brayman, Michael R. Bailey, and Thomas J. Matula*

  • Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington 98105, USA

  • *Corresponding author. matula@apl.washington.edu

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Issue

Vol. 106, Iss. 3 — 21 January 2011

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