• Open Access

Collective Behavior of Antagonistically Acting Kinesin-1 Motors

Cecile Leduc, Nenad Pavin, Frank Jülicher, and Stefan Diez
Phys. Rev. Lett. 105, 128103 – Published 17 September 2010
PDFHTMLExport Citation

Abstract

In many subcellular force-generating systems, groups of motor proteins act antagonistically. Here, we present an experimental study of the tug of war between superprocessive kinesin-1 motors acting on antiparallel microtubule doublets in vitro. We found distinct modes of slow and fast movements, as well as sharp transitions between these modes and regions of coexistence. We compare our experimental results to a quantitative theory based on the physical properties of individual motors. Our results show that mechanical interactions between motors can collectively generate coexisting transport regimes with distinct velocities.

  • Figure
  • Figure
  • Figure
  • Received 1 February 2010

DOI:https://doi.org/10.1103/PhysRevLett.105.128103

This article is available under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.

© 2010 The American Physical Society

Authors & Affiliations

Cecile Leduc1,2, Nenad Pavin3,4, Frank Jülicher3,*, and Stefan Diez1,†

  • 1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
  • 2Centre de Physique Moleculaire Optique et Hertzienne, CNRS-Universite Bordeaux 1, Talence, France
  • 3Max Planck Institute for the Physics of Complex Systems, Dresden 01187, Germany
  • 4Department of Physics, Faculty of Science, University of Zagreb, Zagreb 10002, Croatia

  • *julicher@pks.mpg.de
  • diez@mpi-cbg.de

Article Text

Click to Expand

Supplemental Material

Click to Expand

References

Click to Expand
Issue

Vol. 105, Iss. 12 — 17 September 2010

Reuse & Permissions
Author publication services for translation and copyediting assistance advertisement

Authorization Required


×
×

Images

×

Sign up to receive regular email alerts from Physical Review Letters

Reuse & Permissions

It is not necessary to obtain permission to reuse this article or its components as it is available under the terms of the Creative Commons Attribution 3.0 License. This license permits unrestricted use, distribution, and reproduction in any medium, provided attribution to the author(s) and the published article's title, journal citation, and DOI are maintained. Please note that some figures may have been included with permission from other third parties. It is your responsibility to obtain the proper permission from the rights holder directly for these figures.

×

Log In

Cancel
×

Search


Article Lookup

Paste a citation or DOI

Enter a citation
×