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Pulsating Tandem Microbubble for Localized and Directional Single-Cell Membrane Poration

G. N. Sankin, F. Yuan, and P. Zhong
Phys. Rev. Lett. 105, 078101 – Published 9 August 2010
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Abstract

The interaction of laser-generated tandem microbubble (maximum diameter of about 50μm) with single (rat mammary carcinoma) cells is investigated in a 25μm liquid layer. Antiphase and coupled oscillation of the tandem microbubble leads to the formation of alternating, directional microjets (with max microstreaming velocity of 10m/s) and vortices (max vorticity of 350000s1) in opposite directions. Localized and directional membrane poration (200 nm to 2μm in pore size) can be produced by the tandem microbubble in an orientation and proximity-dependent manner, which is absent from a single oscillating microbubble of comparable size and at the same stand-off distance.

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  • Received 17 May 2010

DOI:https://doi.org/10.1103/PhysRevLett.105.078101

© 2010 The American Physical Society

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Aiming with bubbles

Published 9 August 2010

An alternative to a needle for penetrating cells may be found in the precise and forceful fluid jet created by two bubbles expanding and collapsing in tandem.

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Authors & Affiliations

G. N. Sankin, F. Yuan, and P. Zhong*

  • Department of Mechanical Engineering and Materials Science, Duke University, Box 90300, Durham, North Carolina 27708, USA

  • *Corresponding author: pzhong@duke.edu

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Issue

Vol. 105, Iss. 7 — 13 August 2010

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