Abstract
The interaction of laser-generated tandem microbubble (maximum diameter of about ) with single (rat mammary carcinoma) cells is investigated in a liquid layer. Antiphase and coupled oscillation of the tandem microbubble leads to the formation of alternating, directional microjets (with max microstreaming velocity of ) and vortices (max vorticity of ) in opposite directions. Localized and directional membrane poration (200 nm to in pore size) can be produced by the tandem microbubble in an orientation and proximity-dependent manner, which is absent from a single oscillating microbubble of comparable size and at the same stand-off distance.
- Received 17 May 2010
DOI:https://doi.org/10.1103/PhysRevLett.105.078101
© 2010 The American Physical Society
Viewpoint
Aiming with bubbles
Published 9 August 2010
An alternative to a needle for penetrating cells may be found in the precise and forceful fluid jet created by two bubbles expanding and collapsing in tandem.
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