Transient Binding and Dissipation in Cross-Linked Actin Networks

O. Lieleg, M. M. A. E. Claessens, Y. Luan, and A. R. Bausch
Phys. Rev. Lett. 101, 108101 – Published 5 September 2008
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Abstract

In contrast with entangled actin solutions, transiently cross-linked actin networks can provide highly elastic properties while still allowing for local rearrangements in the microstructure-on biological relevant time scales. Here, we show that thermal unbinding of transient cross-links entails local stress relaxation and energy dissipation in an intermediate elasticity dominated frequency regime. We quantify the viscoelastic response of an isotropically cross-linked actin network by experimentally tuning the off rate of the transiently cross-linking molecules, their density, and the solvent viscosity. We reproduce the measured frequency response by a semiphenomenological model that is predicated on microscopic unbinding events.

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  • Received 30 January 2008

DOI:https://doi.org/10.1103/PhysRevLett.101.108101

©2008 American Physical Society

Authors & Affiliations

O. Lieleg1, M. M. A. E. Claessens1,2, Y. Luan1,3, and A. R. Bausch1

  • 1Lehrstuhl für Biophysik E27, Technische Universität München, Germany
  • 2MESA, Faculty of Science and Technology, University of Twente, The Netherlands
  • 3School of Pharmacy, Shandong University, People’s Republic of China

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Issue

Vol. 101, Iss. 10 — 5 September 2008

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