Effect of head group orientation on phospholipid assembly

Tanay Paul and Jayashree Saha
Phys. Rev. E 95, 062703 – Published 19 June 2017

Abstract

The relationship between bilayer stability and lipid head group orientation is reported. In this work, molecular-dynamics simulations are performed to analyze the structure-property relationship of lipid biomembranes, taking into account coarse-grained model lipid interactions. The work explains the molecular scale mechanism of the phase behavior of lipid systems due to ion-lipid or anesthetic-lipid interactions, where reorientations of dipoles play a key role in modifying lipid phases and thereby alter biomembrane function. Our study demonstrates that simple dipolar reorientation is indeed sufficient in tuning a bilayer to a randomly flipped nonbilayer lamellar phase. This study may be used to assess the impact of changes in lipid phase characteristics on biomembrane structure due to the presence of anesthetics and ions.

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  • Received 23 November 2016

DOI:https://doi.org/10.1103/PhysRevE.95.062703

©2017 American Physical Society

Physics Subject Headings (PhySH)

Interdisciplinary PhysicsStatistical Physics & ThermodynamicsPhysics of Living SystemsPolymers & Soft Matter

Authors & Affiliations

Tanay Paul* and Jayashree Saha

  • Department of Physics, University of Calcutta,92, A. P. C. Road, Kolkata 700009, India

  • *tanaypaul9492@gmail.com
  • jsphy@caluniv.ac.in

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Issue

Vol. 95, Iss. 6 — June 2017

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