Hydrodynamic collective effects of active proteins in biological membranes

Yuki Koyano, Hiroyuki Kitahata, and Alexander S. Mikhailov
Phys. Rev. E 94, 022416 – Published 22 August 2016
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Abstract

Lipid bilayers forming biological membranes are known to behave as viscous two-dimensional fluids on submicrometer scales; usually they contain a large number of active protein inclusions. Recently, it was shown [A. S. Mikhailov and R. Kapral, Proc. Natl. Acad. Sci. USA 112, E3639 (2015)] that such active proteins should induce nonthermal fluctuating lipid flows leading to diffusion enhancement and chemotaxislike drift for passive inclusions in biomembranes. Here, a detailed analytical and numerical investigation of such effects is performed. The attention is focused on the situations when proteins are concentrated within lipid rafts. We demonstrate that passive particles tend to become attracted by active rafts and are accumulated inside them.

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  • Received 1 May 2016
  • Revised 27 July 2016

DOI:https://doi.org/10.1103/PhysRevE.94.022416

©2016 American Physical Society

Physics Subject Headings (PhySH)

Physics of Living Systems

Authors & Affiliations

Yuki Koyano1, Hiroyuki Kitahata1, and Alexander S. Mikhailov2,3,*

  • 1Department of Physics, Graduate School of Science, Chiba University, Chiba 263-8522, Japan
  • 2Abteilung Physikalische Chemie, Fritz-Haber-Institut der Max-Planck-Gesellschaft, 14195 Berlin, Germany
  • 3Department of Mathematical and Life Sciences, Hiroshima University, Hiroshima 739-8526, Japan

  • *Corresponding author: mikhailov@fhi-berlin.mpg.de

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Issue

Vol. 94, Iss. 2 — August 2016

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