Interplay of migratory and division forces as a generic mechanism for stem cell patterns

Edouard Hannezo, Alice Coucke, and Jean-François Joanny
Phys. Rev. E 93, 022405 – Published 8 February 2016
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Abstract

In many adult tissues, stem cells and differentiated cells are not homogeneously distributed: stem cells are arranged in periodic “niches,” and differentiated cells are constantly produced and migrate out of these niches. In this article, we provide a general theoretical framework to study mixtures of dividing and actively migrating particles, which we apply to biological tissues. We show in particular that the interplay between the stresses arising from active cell migration and stem cell division give rise to robust stem cell patterns. The instability of the tissue leads to spatial patterns which are either steady or oscillating in time. The wavelength of the instability has an order of magnitude consistent with the biological observations. We also discuss the implications of these results for future in vitro and in vivo experiments.

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  • Received 9 January 2015

DOI:https://doi.org/10.1103/PhysRevE.93.022405

©2016 American Physical Society

Physics Subject Headings (PhySH)

Physics of Living Systems

Authors & Affiliations

Edouard Hannezo1,2,*, Alice Coucke1,3,4, and Jean-François Joanny1,5

  • 1Physicochimie Curie (Institut Curie/CNRS-UMR 168/UPMC), Institut Curie, Centre de Recherche, PSL Research University, 26 rue d'Ulm, 75248 Paris Cedex 05, France
  • 2Cavendish Laboratory, 19 JJ Thompson Avenue, Cambridge CB3 0HE, United Kingdom
  • 3Laboratoire de Physique Théorique, CNRS-UMR 8549, Ecole Normale Supérieure, 24 Rue Lhomond, 75005 Paris, France
  • 4Biologie Computationnelle et Quantitative, CNRS-UMR 7238, Sorbonne Universités, UPMC Paris 06, France
  • 5ESPCI Paris-Tech, 10 rue Vauquelin, 75005 Paris, France

  • *eh508@cam.ac.uk

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Issue

Vol. 93, Iss. 2 — February 2016

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