Segregation of diffusible and directionally moving particles on a polar filament

D. Johann, D. Goswami, and K. Kruse
Phys. Rev. E 89, 042713 – Published 23 April 2014; Erratum Phys. Rev. E 89, 059904 (2014)

Abstract

Directed transport in living cells relies on the action of motor proteins. These enzymes can transform chemical energy into mechanical work and move directionally along filamentous tracks. At the same time, these filaments serve as a substrate for the binding of proteins performing other functions, but that also obstruct the motors' motion. Motivated by the mobile cross-linker Ase1, we theoretically study a system of molecular motors in the presence of diffusible particles. Both the motors and the obstacles shuttle between the filament and its surrounding. Numerical simulations of this system show a segregation between motors and obstacles if the filament ends act as diffusion barriers for the obstacles. A phenomenological mean-field theory captures the essential effects observed in the simulations.

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  • Received 1 March 2014

DOI:https://doi.org/10.1103/PhysRevE.89.042713

©2014 American Physical Society

Erratum

Authors & Affiliations

D. Johann, D. Goswami, and K. Kruse

  • Theoretische Physik, Universität des Saarlandes, Postfach 151150, 66041 Saarbrücken, Germany

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Issue

Vol. 89, Iss. 4 — April 2014

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