Flexible traffic control of the synfire-mode transmission by inhibitory modulation: Nonlinear noise reduction

Takashi Shinozaki, Masato Okada, Alex D. Reyes, and Hideyuki Câteau
Phys. Rev. E 81, 011913 – Published 22 January 2010

Abstract

Intermingled neural connections apparent in the brain make us wonder what controls the traffic of propagating activity in the brain to secure signal transmission without harmful crosstalk. Here, we reveal that inhibitory input but not excitatory input works as a particularly useful traffic controller because it controls the degree of synchrony of population firing of neurons as well as controlling the size of the population firing bidirectionally. Our dynamical system analysis reveals that the synchrony enhancement depends crucially on the nonlinear membrane potential dynamics and a hidden slow dynamical variable. Our electrophysiological study with rodent slice preparations show that the phenomenon happens in real neurons. Furthermore, our analysis with the Fokker-Planck equations demonstrates the phenomenon in a semianalytical manner.

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  • Received 18 May 2009

DOI:https://doi.org/10.1103/PhysRevE.81.011913

©2010 American Physical Society

Authors & Affiliations

Takashi Shinozaki1,*, Masato Okada2,1, Alex D. Reyes3, and Hideyuki Câteau1,4

  • 1RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
  • 2Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan
  • 3Center for Neural Science, New York University, 4 Washington Place, New York, New York 10003, USA
  • 4Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Kitakyushu, Fukuoka 808-0196, Japan

  • *Present address: Center for Neural Science, New York University, 4 Washington Place, New York, New York 10003, USA.

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Vol. 81, Iss. 1 — January 2010

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