Bimodal oscillations in nephron autoregulation

O. V. Sosnovtseva, A. N. Pavlov, E. Mosekilde, and N.-H. Holstein-Rathlou
Phys. Rev. E 66, 061909 – Published 20 December 2002
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Abstract

The individual functional unit of the kidney (the nephron) displays oscillations in its pressure and flow regulation at two different time scales: fast oscillations associated with a myogenic dynamics of the afferent arteriole, and slower oscillations arising from a delay in the tubuloglomerular feedback. We investigate the intra- and internephron entrainment of the two time scales. In addition to full synchronization, both wavelet analyses of experimental data and numerical simulations reveal a partial entrainment in which neighboring nephrons attain a state of chaotic synchronization with respect to their slow dynamics, but the fast dynamics remain desynchronized.

  • Received 29 July 2002

DOI:https://doi.org/10.1103/PhysRevE.66.061909

©2002 American Physical Society

Authors & Affiliations

O. V. Sosnovtseva1,2, A. N. Pavlov1, E. Mosekilde2, and N.-H. Holstein-Rathlou3

  • 1Physics Department, Saratov State University, Astrakhanskaya Street 83, Saratov, 410026, Russia
  • 2Department of Physics, The Technical University of Denmark, 2800 Kongens Lyngby, Denmark
  • 3Department of Medical Physiology, Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark

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Issue

Vol. 66, Iss. 6 — December 2002

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