Small-angle neutron scattering from multilamellar lipid bilayers: Theory, model, and experiment

Jesper Lemmich, Kell Mortensen, John Hjort Ipsen, Thomas Hønger, Rogert Bauer, and Ole G. Mouritsen
Phys. Rev. E 53, 5169 – Published 1 May 1996
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Abstract

Small-angle neutron scattering data obtained from fully hydrated, multilamellar phospholipid bilayers with deuterated acyl chains of different length are presented and analyzed within a paracrystalline theory and a geometric model that permit the bilayer structure to be determined under conditions where the lamellar layers are coupled and fluctuating. This theory provides structural information in the region of the solid-fluid bilayer phase transition without invoking the usual decoupling of the scattering intensity function into form and structure factors. Results are presented as a function of temperature for the lamellar repeat distance, the hydrophobic bilayer thickness, as well as the thickness of the aqueous and polar head group region. In addition to these geometric parameters the analysis permits determination of molecular cross-sectional area, number of interlamellar water molecules, as well as estimates for response functions such as lateral area compressibility. The results, which are compared to experimental data obtained by other techniques, provide indirect information on interlamellar undulation forces, renormalization of bilayer bending rigidity, and unbinding phenomena in multilamellar stacks. © 1996 The American Physical Society.

  • Received 31 October 1995

DOI:https://doi.org/10.1103/PhysRevE.53.5169

©1996 American Physical Society

Authors & Affiliations

Jesper Lemmich, Kell Mortensen, John Hjort Ipsen, Thomas Hønger, Rogert Bauer, and Ole G. Mouritsen

  • Department of Physical Chemistry, The Technical University of Denmark, Building 206, DK-2800 Lyngby, Denmark
  • Department of Solid State Physics, Riso/ National Laboratory, DK-4000 Roskilde, Denmark
  • Department of Physics, Royal Veterinary and Agricultural University of Denmark, Thorvaldsensvej 40, DK-1871 Frederiksberg, Denmark

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Issue

Vol. 53, Iss. 5 — May 1996

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