Effect of dedifferentiation on noise propagation in cellular hierarchy

Yuman Wang, Jintong Zhao, Hye Jin Park, and Da Zhou
Phys. Rev. E 105, 054409 – Published 18 May 2022

Abstract

Many fast renewing tissues have a hierarchical structure. Tissue-specific stem cells are at the root of this cellular hierarchy, which give rive to a whole range of specialized cells via cellular differentiation. However, increasing evidence shows that the hierarchical structure can be broken due to cellular dedifferentiation in which cells at differentiated stages can revert to the stem cell stage. Dedifferentiation has significant impacts on many aspects of hierarchical tissues. Here we investigate the effect of dedifferentiation on noise propagation by developing a stochastic model composed of different cell types. The moment equations are derived, via which we systematically investigate how the noise in the cell number is changed by dedifferentiation. Our results suggest that dedifferentiation have different effects on the noises in the numbers of stem cells and nonstem cells. Specifically, the noise in the number of stem cells is significantly reduced by increasing dedifferentiation probability. Due to the dual effect of dedifferentiation on nonstem cells, however, more complex changes could happen to the noise in the number of nonstem cells by increasing dedifferentiation probability. Furthermore, it is found that even though dedifferentiation could turn part of the noise propagation process into a noise-amplifying step, it is very unlikely to turn the entire process into a noise-amplifying cascade.

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  • Received 26 August 2021
  • Revised 25 January 2022
  • Accepted 25 April 2022

DOI:https://doi.org/10.1103/PhysRevE.105.054409

©2022 American Physical Society

Physics Subject Headings (PhySH)

  1. Physical Systems
  1. Techniques
Physics of Living Systems

Authors & Affiliations

Yuman Wang1, Jintong Zhao1, Hye Jin Park2,3, and Da Zhou1,*

  • 1School of Mathematical Sciences, Xiamen University, Xiamen 361005, People's Republic of China
  • 2Asia Pacific Center for Theoretical Physics, Pohang 37673, Republic of Korea
  • 3Department of Physics, Inha University, Incheon 22212, Republic of Korea

  • *zhouda@xmu.edu.cn

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Vol. 105, Iss. 5 — May 2022

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