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Phase behavior of blocky charge lattice polymers: Crystals, liquids, sheets, filaments, and clusters

Nicholas A. S. Robichaud, Ivan Saika-Voivod, and Stefan Wallin
Phys. Rev. E 100, 052404 – Published 15 November 2019

Abstract

Motivated by the idea that intrinsically disordered proteins (IDPs) condense into liquidlike droplets within cells, we carry out Monte Carlo simulations of a polymer lattice model to study the relationship between charge patterning and phase separation. Polymer chains containing neutral, positively charged, and negatively charged monomers are placed on a cubic lattice. Only nearest-neighbor interactions between charges are considered. We determine the phase diagram for a systematically varied set of sequences. We observe homogeneous fluids, liquid condensation, cluster phases, filaments, and crystal states. Of the six sequences we study, three form crystals at low temperatures. The other three sequences, which have lower charge densities, instead collapse into gel-like networks or unconnected finite clusters. Longer neutral patches along the sequence sterically limit the size and shape of low-energy structures, which is analogous to the effect of charge or limited valence in attractive colloids. Only one sequence clearly exhibits liquid behavior; this sequence has a reduced tendency to individually fold and crystallize compared to others of similar charge density and draws parallels to real IDP behavior.

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  • Received 18 July 2019

DOI:https://doi.org/10.1103/PhysRevE.100.052404

©2019 American Physical Society

Physics Subject Headings (PhySH)

Physics of Living SystemsPolymers & Soft Matter

Authors & Affiliations

Nicholas A. S. Robichaud, Ivan Saika-Voivod, and Stefan Wallin*

  • Department of Physics and Physical Oceanography, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3X7

  • *swallin@mun.ca

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Issue

Vol. 100, Iss. 5 — November 2019

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