Phase behavior of pure lipid bilayers with mismatch interactions

Zhengping Zhang, Mohamed Laradji, Hong Guo, O. G. Mouritsen, and M. J. Zuckermann
Phys. Rev. A 45, 7560 – Published 1 May 1992
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Abstract

Recently Corvera, Laradji, and Zuckermann (unpublished) showed that the multistate lattice model due to Pink, Green, and Chapman [Biochemistry 20, 6692 (1981)] with parameters obtained from fitting to thermodynamic data for saturated phospholipid bilayers does not exhibit a phase transition but could instead be described in terms of short-range fluctuations close to a critical point. We have extended the Pink-Green-Chapman model by including hydrophobic mismatch interactions between the lipid acyl-chain conformational states. We used Monte Carlo techniques to examine the phase behavior of the extended model and found that it exhibits first-order phase transitions above a critical value of the mismatch parameter. The results are discussed in relation to previous theoretical work as well as experimental measurements on lipid bilayers.

  • Received 14 October 1991

DOI:https://doi.org/10.1103/PhysRevA.45.7560

©1992 American Physical Society

Authors & Affiliations

Zhengping Zhang, Mohamed Laradji, and Hong Guo

  • Centre for the Physics of Materials, Department of Physics, McGill University, Rutherford Building, 3600 University Street, Montréal, Québec, Canada H3A 2T8

O. G. Mouritsen and M. J. Zuckermann

  • Department of Physical Chemistry, The Technical University of Denmark, DK-2800 Lyngby, Denmark

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Vol. 45, Iss. 10 — May 1992

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