Internal Mechanical Response of a Polymer in Solution

Adam E. Cohen and W. E. Moerner
Phys. Rev. Lett. 98, 116001 – Published 14 March 2007
PDFHTMLExport Citation

Abstract

We observed single molecules of fluorescently labeled double-stranded (ds) λ DNA held in an anti-Brownian electrokinetic trap. From the measured density fluctuations we extract the density-density response function of the molecule over times >4.5ms and distances >250nm, i.e., how a perturbation in density in one part of the molecule propagates through the rest of the molecule. We find a nonmonotonic radial dependence of the relaxation time. In contrast with earlier measurements on freely diffusing dsDNA, we observe clear signs of internal hydrodynamic interactions.

  • Figure
  • Figure
  • Figure
  • Figure
  • Figure
  • Received 19 September 2006

DOI:https://doi.org/10.1103/PhysRevLett.98.116001

©2007 American Physical Society

Authors & Affiliations

Adam E. Cohen and W. E. Moerner

  • Departments of Physics and Chemistry, Stanford University, Stanford, California 94305, USA*

  • *Electronic address: acohen@post.harvard.edu

Article Text (Subscription Required)

Click to Expand

Supplemental Material (Subscription Required)

Click to Expand

References (Subscription Required)

Click to Expand
Issue

Vol. 98, Iss. 11 — 16 March 2007

Reuse & Permissions
Access Options
Author publication services for translation and copyediting assistance advertisement

Authorization Required


×
×

Images

×

Sign up to receive regular email alerts from Physical Review Letters

Log In

Cancel
×

Search


Article Lookup

Paste a citation or DOI

Enter a citation
×