Tissue Self-Affinity and Polarized Light Scattering in the Born Approximation: A New Model for Precancer Detection

Martin Hunter, Vadim Backman, Gabriel Popescu, Maxim Kalashnikov, Charles W. Boone, Adam Wax, Venkatesh Gopal, Kamran Badizadegan, Gary D. Stoner, and Michael S. Feld
Phys. Rev. Lett. 97, 138102 – Published 28 September 2006

Abstract

Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.

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  • Received 13 October 2005

DOI:https://doi.org/10.1103/PhysRevLett.97.138102

©2006 American Physical Society

Authors & Affiliations

Martin Hunter1,*, Vadim Backman2, Gabriel Popescu1, Maxim Kalashnikov1, Charles W. Boone1, Adam Wax3, Venkatesh Gopal2, Kamran Badizadegan4, Gary D. Stoner5, and Michael S. Feld1

  • 1G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
  • 2Northwestern University, Evanston, Illinois 60208, USA
  • 3Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
  • 4Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
  • 5The Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA

  • *Electronic address: mhunter@mit.edu

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Vol. 97, Iss. 13 — 29 September 2006

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