Time-Resolved Reflectance at Null Source-Detector Separation: Improving Contrast and Resolution in Diffuse Optical Imaging

Alessandro Torricelli, Antonio Pifferi, Lorenzo Spinelli, Rinaldo Cubeddu, Fabrizio Martelli, Samuele Del Bianco, and Giovanni Zaccanti
Phys. Rev. Lett. 95, 078101 – Published 8 August 2005

Abstract

We propose a novel approach to imaging in diffusive media based on time-resolved reflectance measurements at null source-detector separation. This approach yields better spatial resolution and contrast as compared to the classical approach, which typically employs a separation of 20–40 mm. Results are obtained by an analytical perturbation approach to diffusion theory and on Monte Carlo simulations. Practical implementation with state-of-the-art technology and performance of a complementary approach based on the use of small but not null source-detector separation are also discussed.

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  • Received 23 November 2004

DOI:https://doi.org/10.1103/PhysRevLett.95.078101

©2005 American Physical Society

Authors & Affiliations

Alessandro Torricelli, Antonio Pifferi, Lorenzo Spinelli, and Rinaldo Cubeddu

  • CNR-INFM and CNR-IFN, Politecnico di Milano–Dipartimento di Fisica, piazza Leonardo da Vinci 32, I-20133 Milan, Italy

Fabrizio Martelli, Samuele Del Bianco, and Giovanni Zaccanti

  • Dipartimento di Fisica dell’Università degli Studi di Firenze and Istituto Nazionale per la Fisica della Materia, Via Giovanni Sansone 1, I-50019 Sesto Fiorentino, Florence, Italy

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Issue

Vol. 95, Iss. 7 — 12 August 2005

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