Elastic Correlations in Nucleosomal DNA Structure

Farshid Mohammad-Rafiee and Ramin Golestanian
Phys. Rev. Lett. 94, 238102 – Published 15 June 2005

Abstract

The structure of DNA in the nucleosome core particle is studied using an elastic model that incorporates anisotropy in the bending energetics and twist-bend coupling. Using the experimentally determined structure of nucleosomal DNA [T. J. Richmond and C. A. Davey, Nature (London) 423, 145 (2003)], it is shown that elastic correlations exist between twist, roll, tilt, and stretching of DNA, as well as the distance between phosphate groups. The twist-bend coupling term is shown to be able to capture these correlations to a large extent, and a fit to the experimental data yields a new estimate of G=25nm for the value of the twist-bend coupling constant.

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  • Received 4 December 2004

DOI:https://doi.org/10.1103/PhysRevLett.94.238102

©2005 American Physical Society

Authors & Affiliations

Farshid Mohammad-Rafiee and Ramin Golestanian

  • Isaac Newton Institute for Mathematical Sciences, Cambridge CB3 0EH, United Kingdom
  • Institute for Advanced Studies in Basic Sciences, Zanjan 45195-159, Iran

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Issue

Vol. 94, Iss. 23 — 17 June 2005

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