Neuron-Semiconductor Chip with Chemical Synapse between Identified Neurons

R. Alexander Kaul, Naweed I. Syed, and Peter Fromherz
Phys. Rev. Lett. 92, 038102 – Published 23 January 2004

Abstract

Noninvasive electrical stimulation and recording of neuronal networks from semiconductor chips is a prerequisite for the development of neuroelectronic devices. In a proof-of-principle experiment, we implemented the fundamental element of such future hybrids by joining a silicon chip with an excitatory chemical synapse between a pair of identified neurons from the pond snail. We stimulated the presynaptic cell (VD4) with a chip capacitor and recorded the activity of the postsynaptic cell (LPeD1) with a transistor. We enhanced the strength of the soma-soma synapse by repetitive capacitor stimulation, establishing a neuronal memory on the silicon chip.

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  • Received 29 August 2003

DOI:https://doi.org/10.1103/PhysRevLett.92.038102

©2004 American Physical Society

Authors & Affiliations

R. Alexander Kaul1, Naweed I. Syed2, and Peter Fromherz1,*

  • 1Department of Membrane and Neurophysics, Max Planck Institute for Biochemistry, Martinsried/Munich, Germany 82152
  • 2Respiratory and Neuroscience Research Groups, University of Calgary, Calgary, Canada T2N 4N1

  • *To whom correspondence should be addressed. Electronic address: fromherz@biochem.mpg.de

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Vol. 92, Iss. 3 — 23 January 2004

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