Preferential Attachment in the Protein Network Evolution

Eli Eisenberg and Erez Y. Levanon
Phys. Rev. Lett. 91, 138701 – Published 26 September 2003

Abstract

The Saccharomyces cerevisiae protein-protein interaction map, as well as many natural and man-made networks, shares the scale-free topology. The preferential attachment model was suggested as a generic network evolution model that yields this universal topology. However, it is not clear that the model assumptions hold for the protein interaction network. Using a cross-genome comparison, we show that (a) the older a protein, the better connected it is, and (b) the number of interactions a protein gains during its evolution is proportional to its connectivity. Therefore, preferential attachment governs the protein network evolution. Evolutionary mechanisms leading to such preference and some implications are discussed.

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  • Received 24 March 2003

DOI:https://doi.org/10.1103/PhysRevLett.91.138701

©2003 American Physical Society

Authors & Affiliations

Eli Eisenberg and Erez Y. Levanon

  • Compugen Ltd., 72 Pinchas Rosen Street, Tel Aviv 69512, Israel

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Issue

Vol. 91, Iss. 13 — 26 September 2003

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