Epigenetics as a First Exit Problem

E. Aurell and K. Sneppen
Phys. Rev. Lett. 88, 048101 – Published 8 January 2002
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Abstract

We develop a framework to discuss the stability of epigenetic states as first exit problems in dynamical systems with noise. We consider in particular the stability of the lysogenic state of the λ prophage. The formalism defines a quantitative measure of robustness of inherited states.

  • Received 3 March 2001

DOI:https://doi.org/10.1103/PhysRevLett.88.048101

©2002 American Physical Society

Authors & Affiliations

E. Aurell1,2,3 and K. Sneppen3

  • 1SICS, Box 1263, SE-164 29 Kista, Sweden
  • 2SANS/NADA/KTH, SE-100 44 Stockholm, Sweden
  • 3NORDITA, Blegdamsvej 17, DK-2100 Copenhagen, Denmark

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Vol. 88, Iss. 4 — 28 January 2002

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