Picometer-Scale Dynamical X-Ray Imaging of Single DNA Molecules

Yuji C. Sasaki; Yasuaki Okumura; Shinichi Adachi; Hitoshi Suda; Yoshio Taniguchi; Naoto Yagi

doi:10.1103/PhysRevLett.87.248102

Picometer-Scale Dynamical X-Ray Imaging of Single DNA Molecules

Yuji C. Sasaki, Yasuaki Okumura, Shinichi Adachi, Hitoshi Suda, Yoshio Taniguchi, and Naoto Yagi

Phys. Rev. Lett. 87, 248102 – Published 26 November 2001

Abstract

Time-resolved dynamical x-ray imaging of individual DNA molecules with picometer-scale precision is demonstrated for the first time. Diffracted x-ray tracking (DXT), a single-molecule experiment with x rays, monitors the rotating motions, rather than the translational motions, of a labeled nanocrystal. DXT can obtain information about the dynamics of single molecules through a quantitative analysis, since the signals from DXT are independent of the chemical conditions.

Received 20 February 2001

DOI:https://doi.org/10.1103/PhysRevLett.87.248102

Authors & Affiliations

Yuji C. Sasaki^1,2,*, Yasuaki Okumura³, Shinichi Adachi⁴, Hitoshi Suda⁵, Yoshio Taniguchi³, and Naoto Yagi¹

¹Biomedical Group, Japan Synchrotron Radiation Research Institute, SPring-8, Mikazuki, Hyogo 679-5198, Japan
²Unit Process and Combined Circuit, PRESTO, Japan Science and Technology Corporation (JST), Osaka 560-0082, Japan
³Faculty of Textile Science & Technology, Shinshu University, Ueda, Nagano 386-8567, Japan
⁴The Institute of Physical and Chemical Research (RIKEN), Mikazuki, Hyogo 679-5143, Japan
⁵Department of Biological Science and Technology, Tokai University, Numazu, Shizuoka 410-0321, Japan