Near-Field Scanner for Moving Molecules

Jonas O. Tegenfeldt, Olgica Bakajin, Chia-Fu Chou, Shirley S. Chan, Robert Austin, Wunshain Fann, Lim Liou, Eugene Chan, Thomas Duke, and Edward C. Cox
Phys. Rev. Lett. 86, 1378 – Published 12 February 2001
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Abstract

We have fabricated using electron beam nanolithography a fixed slit near-field optical scanning device which uses near-field fluorimetry to achieve 200 nm spatial resolution of objects moving over the slits. We explore the basic physics of operating narrow slits in the waveguide cutoff mode and present data from the passage of extended double-stranded DNA molecules passing over the slits as a first example of how this device can be used to do ultrahigh spatial resolution mapping of long polymers.

  • Received 13 March 2000

DOI:https://doi.org/10.1103/PhysRevLett.86.1378

©2001 American Physical Society

Authors & Affiliations

Jonas O. Tegenfeldt1, Olgica Bakajin1, Chia-Fu Chou1, Shirley S. Chan1, Robert Austin1, Wunshain Fann2, Lim Liou2, Eugene Chan3, Thomas Duke4, and Edward C. Cox5

  • 1Department of Physics, Princeton University, Princeton, New Jersey 08544
  • 2Institute of Atomic and Molecular Sciences, Academia Sinica and Department of Physics, National Taiwan University, Taipei, Taiwan
  • 3U.S. Genomics, Woburn, Massachusetts 01801
  • 4Cavendish Laboratory, Cambridge University, Cambridge, CB3 0HE, United Kingdom
  • 5Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544

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Vol. 86, Iss. 7 — 12 February 2001

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